The Diocese of Pekhon, where the evangelization works initiated by the PIME Missionaries in the late 19th century, initially belonged to the Archdiocese of Taunggyi. As the mission territory was far distant and the number of believers was considerably increasing, it was established a Diocese by His Holiness, Pope Benedict XVI, on December 15, 2005, as a Suffragan of the Archdiocese of Taunggyi. It was inaugurated by His Grace Msgr. Salvatore Pennacchio, the Apostolic Delegate to the Union of Myanmar, on April 1, 2006. Msgr. Peter Hla, the Auxiliary Bishop of Taunggyi, was installed as its first Ordinary on the same day.

Pekhon Diocese is situated in the Southern part of Shan State, in the Eastern part of Myanmar, and comprised of five townships: Pekhon, Pinlaung, Naungtaya, Hsi Hseng and Maukmai. Pekhon Diocese covers an area of about 10,150 square miles, and is mostly hilly and mountainous. It has borders with Taunggyi Archdiocese in the East and in the North, Mandalay Archdiocese in the West, Loikaw Diocese in the South and Taungngu Diocese in the South West. The approximate population in Pekhon Diocese is about 298,690. Buddism is the predominant religion whereas Christianity, Animism and a few other religions are minority. There are many ethnic minorities in Pekhon Diocese, such as, Shan, Pa-Oh, Intha, Kayan, Kayah, Lisu and so on.